دانلود کتاب تمرین شیمی دارویی
The Practice of Medicinal Chemistry, 4ed

Review

About the Author

Contents

Chapter 1. Medicinal Chemistry: Definitions and Objectives, Drug Activity Phases, Drug Classification Systems
Chapter 2. Evaluation of the Biological Activity of Compounds: Techniques and Mechanism of Action Studies
Chapter 3. Drug Targets, Target Identification, Validation, and Screening
Chapter 4. Strategies in the Search for New Lead Compounds or Original Working Hypotheses
Chapter 5. Natural Products as Pharmaceuticals and Sources for Lead Structures
Chapter 6. In Silico Screening: Hit Finding from Database Mining
Chapter 7. Fragment-Based Drug Discovery
Chapter 8. Molecular Variations Based on Isosteric Replacements
Chapter 9. Ring Transformations
Chapter 10. Macrocycles: Under-Explored and Poorly Exploited Drug Class Despite the Proven Therapeutic Potential
Chapter 11. Conformational Restriction and Steric Hindrance in Medicinal Chemistry
Chapter 12. Application Strategies for the Primary Structure–Activity Relationship Exploration
Chapter 13. Substituent Groups
Chapter 14. The Role of Functional Groups in Drug–Receptor Interactions
Chapter 15. Compound Properties and their Influence on Drug Quality
Chapter 16. Pharmacological Space
Chapter 17. Systems Biology: A New Paradigm for Drug Discovery
Chapter 18. Optical Isomerism in Drugs
Chapter 19. Multitarget Drugs: Strategies and Challenges for Medicinal Chemists
Chapter 20. Selective Optimization of Side Activities (SOSA) in Drug Discovery
Chapter 21. Pharmacophore Identification and Pseudo-Receptor Modeling
Chapter 22. Protein Crystallography and Drug Discovery
Chapter 23. Physiological Aspects Determining the Pharmacokinetic Properties of Drugs
Chapter 24. Biotransformation Reactions and their Enzymes
Chapter 25. Biotransformations Leading to Toxic Metabolites: Chemical Aspects
Chapter 26. Drug Transport Mechanisms and their Impact on the Disposition and Effects of Drugs
Chapter 27. Strategies for Enhancing Oral Bioavailability and Brain Penetration
Chapter 28. Designing Prodrugs and Bioprecursors
Chapter 29. Drug Delivery with Organic Solvents or Colloidal Dispersed Systems
Chapter 30. Preparation of Water-Soluble Compounds by Covalent Attachment of Solubilizing Moieties
Chapter 31. Improving the Water-Solubility of Compounds by Molecular Modification to Disrupt Crystal Packing
Chapter 32. Chemical and Physicochemical Approaches to Solve Formulation Problems
Chapter 33. Discover a Drug Substance, Formulate, and Develop It to a Product
Chapter 34. Drug Nomenclature
Chapter 35. Web Alert: Using the Internet for Medicinal Chemistry
Chapter 36. Protection of Inventions in Medicinal Chemistry