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Dendrites, 3ed

Dendrites are complex neuronal structures that receive and integrate synaptic input from other nerve cells. They therefore play a critical role in brain function. Although dendrites were discovered over a century ago, due to the development of powerful new techniques there has been a dramatic resurgence of interest in the properties and function of these beautiful structures.

This is the third edition of the first book devoted exclusively to dendrites. It contains a comprehensive survey of the current state of dendritic research across a wide range of topics, from dendritic morphology, evolution, development, and plasticity through to the electrical, biochemical and computational properties of dendrites, and finally to the key role of dendrites in brain disease. The third edition has been thoroughly revised, with each chapter updated or completely rewritten by leading experts, plus the addition of a number of new chapters.

“Dendrites” will be of interest to researchers and students in neuroscience and related fields, as well as to anyone interested in how the brain works.

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Contents

۱ Dendrite structure
۲ Evolution and scaling of dendrites
۳ Dendrite development
۴ Molecular determinants of dendrite and spine development
۵ Local translation in dendrites
۶ Structure and molecular organization of the postsynaptic density
۷ Subcellular distribution of ligand- and voltage-gated ion channels
۸ Neurotransmitter-gated ion channels in dendrites
۹ Dendritic voltage-gated ion channels
۱۰ Biochemical compartmentalization in dendrites
۱۱ Spine calcium signaling
۱۲ Principles of dendritic integration
۱۳ Dendritic integration in vivo
۱۴ Modeling dendrites: a personal perspective
۱۵ A theoretical view of the neuron as an input-output computing device
۱۶ Toward a simplified model of an active dendritic tree
۱۷ Modeling dendrite shape
۱۸ Functional plasticity at dendritic synapses
۱۹ Structural plasticity in dendrites and spines
۲۰ Molecular signaling during plasticity of dendritic spines
۲۱ Dendrites as transmitters
۲۲ Dendritic connectomics
۲۳ Linking dendritic processing to computation and behavior in invertebrates
۲۴ Dendrites and disease
۲۵ The future of dendrite research